Lucky Pat Adams had no idea that she would be getting a visit from the silver-haired fox.
He turned up unexpectedly at the Sunrise of Sonning care home on Sunday to see resident Pat Adams.
Speaking on Good Morning Britain, she was asked if she'd been starstruck: 'No, I was just thrilled to meet him.
'We started Wish Upon A Star six months ago and asked residents to let us know what they'd like with the promise we'd try and make their wish come true'. Staffer Linda Jones posted a pic of herself with Pat and Clooney, who wore a leather jacket and a wide smile.
George, who lives near to Pat's care home, decided on a visit after seeing in the home's newsletter that her birthday wish was to have a photograph with him.
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The nursing home went on social media and thanked the Oscar victor for the very special visit. "He bought a card and a lovely bunch of flowers".
"This was a classy gesture from a wonderful man", a Sunrise spokesperson told the BBC, adding that Clooney was holding the letter from the staff when he rang the doorbell.
Clooney moved to Sonning, where he lives with his pregnant human rights lawyer wife Amal, in 2014.
Last month, George's mother Nina confirmed that the British-Lebanese barrister (born Alamuddin) is expecting twins - a boy and a girl.