La Roja hosts Israel in a World Cup qualifier in Gijon on March 24 before a friendly with France in Paris four days later.
Pedro returns for the first time in Lopetegui's reign as national team boss after controversial comments during Euro 2016 that he would consider retiring from worldwide football as he didn't want to "make up the numbers". His last match was Spain's 2-0 loss to Italy in the last at Euro 2016.
Diego Costa, Pedro and Cesar Azpilicueta have made Spain's latest squad but Marcos Alonso and Cesc Fabregas have failed to make the cut.
"It is the first time Pedro is with us, but he is well-known in the national team", said Lopetegui.
USA says global trade must be fair as well as free
But they have so far been unable to bridge the differences between the United States and other leading G20 members over trade. By contrast, last year's statement called on all G20 states to resist "all forms" of protectionism.
Lopetegui gave Real Sociedad midfielder Asier Illarramendi his first call-up to the national team at 27, and recalled former Barcelona youth star Gerard Deulofeu.
Deulofeu, who now plays for AC Milan, played 12 minutes in a World Cup preparation game in 2014 and makes his second appearance, while Illaramendi makes his debut.
Julen Lopetegui has named the uncapped Asier Illarramendi in his 25-man squad for matches against Israel and France.
"We know Deulofeu very well but he was not playing on a regular basis before".