A tree from the top of the waterfalls fell onto the sightseers who were swimming.
Ghana National Fire Service spokesman Prince Billy Anaglate said that 18 people died at the scene and two others died in hospital - but the overall death toll remains unclear.
It happened during a storm on Sunday at the waterfall in Kintampo, a popular bathing spot in Ghana's central Brong-Ahafo region.
Following the tragedy that befell one of Ghana's most popular tourist destinations, Kintampo Waterfalls, leading to the loss of over 17 lives, the Kintampo North Municipal Security Council has temporally closed down the destination. "Let's also ask the almighty God to heal the injured and receive the souls of the departed into his kingdom".
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Twenty people have reportedly died after a tree fell down at Kintampo Falls in Ghana.
233livenews.com reported that some students of the University of Energy and Natural Resources were also involved in the accident. Rescue teams worked with chainsaws to clear those who were trapped.
Vice President Dr Mahamadu Bawumia has paid a visit to Kintampo in the Bono Ahafo region where a freak disaster at a tourist site has resulted in a tragic loss of 20 revelers.
A further 20 people were being treated in hospital, Desmond Owusu Boampong, a local police commander, told Reuters.