New drug cuts cholesterol significantly

New drug cuts cholesterol significantly

New drug cuts cholesterol significantly

The results of a two-year clinical trial on the drug sold as Repatha by Amgen Phamaceuticals that costs more than $14,000 a year were released at the American College of Cardiology annual conference in the USA capital. All the patients were taking cholesterol-lowering statins, most at high doses.

Excitement about Repatha - also called evolocumab - has been building in the past three years, with scientists predicting it could "switch off" heart disease.

The data also show similar clinical benefit with evolocumab when analyzed according to baseline LDL levels, even in patients in the lowest quartile of baseline LDL cholesterol, in whom evolocumab reduced LDL cholesterol from 73 to 22 mg/dL.

"To what extent these new results help expand the population eligible for these drugs needs careful analyses of costs versus benefits and each health authority will need to do their calculations".

Atara Biotherapeutics Inc. ( ATRA ) expects initial data from its phase I trial of autologous version of ATA188 in patients with primary and secondary progressive multiple sclerosis to be presented by its collaborating investigators at a medical conference in late April. The researchers randomized patients to receive either injections of Repatha or placebo, and followed them for 2 years to track several cardiovascular events: heart attack, stroke, death, hospitalization for blocked blood flow to the heart, and stent or bypass surgery.

It means that if all 325,000 eligible Britons were to be treated, 2,200 potentially fatal heart emergencies would be avoided every year. By inhibiting the binding of PCSK9 to LDLRs, evolocumab increases the number of LDLRs available to clear LDL from the blood, thereby lowering LDL-C levels.

The investigation concluded that patients who received the evolocumab treatment had their risk of myocardial infarction, stroke, and coronary revascularization reduced.

To compensate, Amgen had the FOURIER study analyzed to look at the Repatha benefit starting at one year, focused on just heart attacks and strokes - the two adverse outcomes doctors care most about.

Israel threatens to destroy Syrian air defenses
The group is sworn to Israel's destruction, and fired thousands of rockets into Israel during a monthlong war in 2006. Russian Federation and Israel's arch-foe Iran has supported Syrian President Bashar al-Assad's regime in the war.

Prof Peter Sever, from Imperial College London - which led the United Kingdom branch of the study, said: "This is one of the most important trials of cholesterol-lowering since the first statin trial, published 20 years ago". Reviews of evolocumab have been mixed, with some physicians hailing the results as major progress against heart disease, while others expected more from the expensive drug.

However, the findings, published in the New England Journal of Medicine, found that the drug had no impact on the rate of cardiovascular mortality.

Patients report few side effects from Repatha, which acts differently than statins and does not cause the muscle pain and weakness that some statin users experience. More than 80 percent had suffered heart attacks, and some had histories of stroke and peripheral artery disease.

The drugs, evolocumab (Repatha) and inclisiran, both work by targeting PCSK9, an enzyme that regulates the liver's ability to remove "bad" LDL cholesterol from the bloodstream. But with a high price tag, it remains to be seen who will be able to afford the drug.

But they were approved only for those with a genetic condition that means they have dangerously high cholesterol, and people with heart disease who can not cope with the side effects of statins. But the evidence of a benefit is strong enough that he will discuss the drug as an option with his patients, he adds.

"The drug was safe and well-tolerated", said lead study author Marc Sabatine, chair of cardiovascular medicine at Brigham and Women's Hospital in Boston.

British Heart Foundation medical director Nilesh Samani said the trial was a significant advance.

"We should still probably reserve these for the highest-risk patients where statins are not doing a good enough job, at least at the price they are now offered", said Lloyd-Jones.

Recommended News

  • Nubia launches Z11 Mini S in India with 23MP camera

    Nubia launches Z11 Mini S in India with 23MP camera

    Like mentioned earlier, the Z11 MiniS comes with a 23MP rear camera with PDAF, six-piece (6P) lens, and LED flash support. On the front, the Z11 Mini S comes with a 13-megapixel camera with f/2.2 aperture and Phase Detection Autofocus.

    Newman skips late pit stop, stuns NASCAR field in Phoenix

    Martin Truex Jr., last week's victor in Las Vegas, had an air gun jam on a pit stop when he was running around the top 10. Logano had the fastest lap through two rounds, but the top 12 have to start from scratch and qualify in the third round.
    Trump Seeks $2.5B Cut For DOL Budget

    Trump Seeks $2.5B Cut For DOL Budget

    But the real story here is the cataclysmic effect Trump's dystopian budget will have on the lives of ordinary Americans. That same reporter asked Mulvaney if the White House had considered the "impact on property values".
  • Trump's $1.1tr budget seeks to boost military

    To hike the Pentagon budget by $54 billion, he said , the president chose to make corresponding $54 billion cuts elsewhere. So they may not have time to actually read everything that comes across their desks before the next tweet or blog post .
    Ocean splash down of the SpaceX Dragon Capsule coming from the ISS

    Ocean splash down of the SpaceX Dragon Capsule coming from the ISS

    NASA astronaut Shane Kimbrough and ESA astronaut Thomas Pesquet from France were the ones to send the spacecraft back to Earth. The Dragon flew to the space station a month ago from the same Florida launch pad used for NASA's Apollo moon shots.

    Trump takes on media again, calls meeting with Merkel 'great'

    By Friday afternoon, Fox News anchor Shepard Smith said that his organization could not verify Napolitano's claims. He appeared on the network earlier this month after President Trump tweeted his wiretapping claim. "Nothing found.
  • Morning After: Clippers sail past Cavaliers 108-78

    Morning After: Clippers sail past Cavaliers 108-78

    Starting Monday night at Staples Center against the New York Knicks, the Clippers next three opponents all have losing records . D'Angelo Russell, who hit seven 3-pointers, scored a career-high 40 points for the Lakers, who lost their fifth in a row.

    Syria fires missiles at Israeli warplanes on bombing run

    Palmyra, once held by ISIS and retaken by the Syrian government, is strategically important to both the regime and its opponents. According to the report, Assayed was with the national defense militia, which fights alongside regime troops.

    Tillerson Meets With Chinese President To Wrap Up Asia Trip

    Trump, during his campaign, branded China a currency manipulator, accused it of "raping" the US , and he pledged steep tariffs. Xi welcomes President Donald Trump to visit China, according to People's Daily, the Communist Party's flagship newspaper.
  • Late block helps Kentucky over Wichita, back to Sweet 16

    Late block helps Kentucky over Wichita, back to Sweet 16

    Meeks, battling for position with Moses Kingsley inside in the paint, tapped it up and in to push the Tar Heels to the 68-65 lead. In 2014, Kentucky knocked off the top-seeded Shockers 78-76 when Fred VanVleet's three-pointer bounced off the rim in St.
    Woman claims an OC restaurant employee asked her for 'proof of residency'

    Woman claims an OC restaurant employee asked her for 'proof of residency'

    She told the Register she is anxious incidents like these will continue because of the political climate surrounding immigration. Saint Marc could not be reached for comment, so we don't know to what degree the incident has affected the restaurant's profits.
    YouTube's 'restricted mode' is hiding LGBT content from viewers

    YouTube's 'restricted mode' is hiding LGBT content from viewers

    A number of vloggers have accused YouTube of filtering their LGBTQ+ content in the platform's Restricted Mode , reports Gizmodo . For the social justice warriors who demanded more censorship, welcome to the new YouTube.

We are pleased to provide this opportunity to share information, experiences and observations about what's in the news.
Some of the comments may be reprinted elsewhere in the site or in the newspaper.
Thank you for taking the time to offer your thoughts.