Goals from Christian Eriksen and Dele Alli - the latter a penalty - in an effective display underlined that Spurs are more than just their talismanic 24-goal striker.
As he trudged off in the 30th minute Dele Alli was fouled in the area by Southampton skipper Steven Davis and Alli picked himself up to stroke home a penalty to put Spurs two up.
Southampton legend Matt Le Tissier has done his former club no favours after insisting that the Saints go to Tottenham with "nothing to fear" with Harry Kane out injured. "It's hard because there's 10 days without our players on the global break, but we hope all will come back in good condition".
Who will come out on top in the battle of the managers Mauricio Pochettino or Claude Puel? 10 place for Southampton while they have only 33 points from 26 matches.
Despite Southampton being deadly in front of goal in recent outings, the statistics suggest a home win today, as Spurs are still yet to lose a home league games this season.
Spurs thought they had found the key to Southampton's success when they poached Paul Mitchell and his "black box" to head up recruitment in November 2014 but they were sold a dud.
Ringo Starr, Brian Wilson and more pay tribute to Chuck Berry
Whatever the music was named, Bruce Springsteen , one of many artists heavily influenced by Berry, said the man was indispensable. The song's opening riff is a clarion call adjudged as the greatest intro in rock-and-roll history by many worldwide.
Substitute Vincent Janssen saw his powerful strike pushed away by Forster as the game entered its closing minutes, and Tottenham saw out five minutes of stoppage time to take another three home points.
With all being said, I expect a very open game with a lot of running on the sides, while at the same time the final outcome will most likely depend on the pure strategy of both teams.
Ryan Bertrand fired a ball in from the left and, as Toby Alderweireld kicked the air, Ward-Prowse was able to bundle it in at the back post.
"Finding the net hasn't been a problem for Southampton lately, who have won their last two away games at Sunderland and Watford, scoring four in each of them".
It was the South Korean who moved into the striker role following Kane's injury last weekend against Millwall, and promptly scored a hat-trick of goals in the 6-0 win.
Liverpool matchup is very tempting to analyze, we have chose to switch our focus on the 2nd ranked Tottenham who will host the 10th ranked Southampton at the White Hart Lane.